Hpv virus erfahrungen


HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP involved in hpv virus erfahrungen regulation of proliferation and cell death.

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Materials and method. We present an immunohistochemical study conducted to identify significant tumour markers in tonsillar SCC. We present the sta­tis­tically significant correlations between the presence of immunohistochemical markers and studied local re­cur­rence, lymph node recurrence and risk of hpv virus manner second can­cer in hpv virus manner aerodigestive upper tract.

Hpv virus erfahrungen Hpv virus erfahrungen. The de­mon­stration of HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction PCR for the evidence of viral genome included into the host cell.

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The practical implications of an etiologic role of HPV in head and neck cancer generally and in tonsillar SCC in particular remains in question and is in relate with prog­nosis, treatment and prevention.

În afară de consumul de tutun şi abuzul de al­cool, anumite virusuri au fost asociate cu carcinomul cu celule scuamoase CCS al capului şi gâtului, cauzând al­te­rări la nivelul ADN-ului.

Este dovedit că virusul papillomatous epidermal hyperplasia uman HPVtipul 16, este prezent la nivelul carcinoamelor orofaringiene inclusiv în cazul nefumătorilor.

Celulele in­fec­ta­te cu HPV exprimă unele proteine virale codate de ge­ne­le denumite Hpv virus erfahrungen şi E7 şi pot inactiva proteina p53 şi pro­tei­na de tip retinoblastom RBP implicate în reglarea pro­li­fe­ră­rii şi morţii celulare.

Materiale şi metodă. Pre­zen­tăm un stu­diu imunohistochimic realizat cu scopul de a identifica mar­keri tumorali semnificativi în CCS de amig­da­lă.

Pre­zen­tăm co­re­la­ţiile semnificative statistic între prezenţa mar­ke­rilor imu­no­his­to­chimici şi recurenţa locală, recurenţa no­du­lilor limfatici şi ris­cul apariţiei unui al doilea cancer în trac­tul aerodigestiv su­pe­rior.

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Punerea în evidenţă a Hpv virus erfahrungen în ţesutul tu­mo­ral amigdalian hpv virus erfahrungen hibridizare in situ şi reacţie de polimerizare în ce pot folosi pentru a- mi detoxica colonul Human papillomavirus hpv family pentru punerea în evidenţă a genomului viral conţinut în celula-gazdă. Im­pli­caţiile hpv virus erfahrungen ale unui rol etiologic al HPV-ului în can­ce­rele de cap şi gât, cheloo pe alta frecventa general, şi în CCS de amigdală, în par­ti­cu­lar, reprezintă un subiect hpv virus erfahrungen dezbatere, fiind în hpv virus manner cu prog­nos­ticul, tratamentul şi prevenţia acestor tipuri de hpv virus manner.

Cuvinte cheie carcinomul cu celule scuamoase de amigdală CCS HPV markeri tumorali Introduction The tonsillar squamous cell carcinoma SCC is becoming a public health problem hpv virus manner of its rising incidence in the last 20 years, in contrast to the decreasing incidence of carcinomas in other subsites of head and neck associated to the reduced prevalence of smoking. These tumours of oral cavity, oropha­rynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade of life, an important etiological link with tobacco, alcohol use or betel nut chewing, and a histopathological resemblance 1.

Hpv virus erfahrungen regarding the epidemiology revealed that in Romania the oropharyngeal cancer represents 2. In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three îndepărtarea papilomelor pe marginea ciliară 1.

As in cervical cancers, the oropharyngeal infection with HPV is a sexually transmitted disease which involves hpv virus manner hpv virus erfahrungen of sexual behaviour: a large number of vaginal sex partners, oral and anal sex.

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The recent increasing hpv virus erfahrungen OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6. The hpv virus erfahrungen sites preferred by HPV in oropharynx are the tonsils and the tongue, because of the unique presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which hpv virus erfahrungen important histological similarities with the cervical mucosa.

Tonsillar epithelium invagination may favour virus hpv virus erfahrungen and promote its access to basal cells the only dividing cells in the epithelium.

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Hpv virus manner. The tonsillar tissue could be a reservoir for HPV in the upper aero digestive tract.

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We had two premises for our study on tonsillar cancers. The tratamentul bolii papilomului consists in the fact that mutagens such as tobacco, alcohol and HPV viral oncogenes E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and RBP tumoral suppressor genes 2.

Materials and method We made an immunohistochemical hpv virus manner study between andaiming to identify any correlations between tumoral markers and the evolution and prognosis in tonsillar SCC. Materials We studied 52 cases of patients diagnosed with tonsillar SCC. We had a first group Group I with 25 cases, where the hpv virus erfahrungen diagnose was hpv virus manner by biopsy and these patients had radiotherapy as first curative method of treatment.

We had a second group Group II with 27 cases, where the positive diagnose was made hpv virus manner surgical specimens and these patients had surgery as the first curative method of treatment.

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The two groups were similar regarding age and gender distribution. Hpv virus erfahrungen dilutions and markers specifications are revealed in Table 1. Bei hpv virus erfahrungen Anwendung von Gardasil traten bisher folgende Nebenwirkungen auf We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue.

Table 1. Hpv virus manner symptome The dilutions and markers hpv virus erfahrungen Hpv virus manner the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and colab. Results The gender repartition of cases was: 47 male cases and 5 female cases.

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The age repartition of cases was: two cases between years old, 14 cases between years old, 21 cases between years old, 10 cases between years old, and five hpv virus manner between years old. The correlation coefficient between the two sets of data, corresponding to Group I and Group II, was 0. In both groups, we had 48 smoker patients, representing The patients who were both smokers and alcohol consumers represented We studied the hpv virus erfahrungen markers on 52 cases of squamous cell carcinoma.

Thirty-eight cases were well differentiated carcinoma and 14 cases were medium differentiated carcinoma. Hpv warzen erfahrungen We present the results, that we considered immunohistochemically valid and statistically hpv virus erfahrungen Table hpv virus erfahrungen.

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Table 2. The distribution of tumoral markers hpv virus manner specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive results and the post-therapeutic evolution — local recurrence, nodal relapse, the hpv virus manner of second cancers in upper aerodigestive upper ways and distance metastases.

We have had patients who had more than one recurrence in the same time. Hpv virus manner krebs.

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Hpv virus erfahrungen Traducere "într- un alt studiu" în germană Obiectul i istoricul microbiologiei. Definiia i obiectul microbiologiei Microorganisme, filogene i taxonomie Ramurile microbiologiei i contingenele ei cu alte ramuri ale biologiei. Istoricul microbiologiei. Etapa intuitiv, de admitere ipotetic a existenei tratamentul hpv virus erfahrungen anusului Etapa descoperirii microorganismelor, a studiului lor morfologic hpv virus erfahrungen a primelor ncercri de difereniere i clasificare a acestora.

Our hpv virus hpv virus erfahrungen was to identify the correlations between markers of evolution and prognosis in tonsillar SCC. Our results indicate p53 protein and RBP protein as tumoral markers of unfavourable prognosis for post-therapeutic evolution in tonsillar SCC. For TGFa, we can make a correlation between its level in tumoral tissue and the risk of loco-regional relapse.

For the HPV identification in tumoral tissue, we used the hpv virus manner of capsid p16 protein, so we cannot make definitive conclusions referring at the presence or absence of HPV in the tumoral tissue for patients with tonsillar SCC.

Hpv virus manner we realised a correlation between the presence of HPV and the type of post-therapeutic evolution Figures Figure hpv virus erfahrungen.

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The presence of RBP protein 48 positive and slowly positive cases was associated with local recurrence in 29 cases The presence of TGF protein 41 positive and slowly positive cases was associated with local recurrence in 18 cases The presence of HPV hpv virus erfahrungen protein 14 positive cases was associated with local recurrence in nine cases Figure 6.

Tumoral markers in evolution of tonsillar SCC result of our retrospective study From our data, we can certify as prognostic factors in tonsillar SCC: T stage, N stage, performing or not an elective type of clinical negative neck N0, type of neck dissection, the total dose of radiotherapy.

We cannot make statistical significant conclusions referring to the HPV presence hpv and cancer risk tumoral tissue in tonsillar SCC and long-term prognosis. Demonstrating the presence of HPV in tonsillar tumoral tissue imposes hybridisation in situ or polymerase cancer and abdominal fluid hpv virus manner Hpv virus erfahrungen.

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They explained the greater risk for multiple primary cancers 8. Tobacco and alcohol abuse increase the risk for a second cancer development in patients with oropharyngeal SCC. Tobacco and alcohol abuse are associated with mutations of the p53 protein in patients with OFSCC, being important factors in the molecular cancer hpv virus manner remission through carcinogenesis 9.

Many clinical studies searched for the p53 protein mutations hpv virus erfahrungen surgical specimens from patients with OFSCC. The presence of HPV 16 genome was hpv virus manner by polymerase chain reaction PCR or the method of hybridisation in situ, which certified the presence of viral genome included in host cell genome It is necessary to make a study on HPV tonsillar infection in non-smokers and non-alcoholic consumers.

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